Research of daily arterial stiffness dynamics with the use of ambulatory blood pressure monitoring 
A.E.Nosov
GOU VPO “Roszdrav’s Perm State Medicine Academy after E.A.Wagner”
Hospital therapy department №1 with the course of ambulatory therapy
Head of department – Doctor of Medicine, Professor A.V.Tuev
Doctor of Medicine, Associated Professor – A.V. Agafonov

Purpose: Application of new analysis approach for blood pressure monitoring (BPM) data among hypertensive patients for arterial stiffness diagnostics and its daily dynamics study. 62 patients were inspected. Patients were randomized in 2 groups: patients with arterial hypertension and normal tension. Special research of blood pressure monitoring was conducted with the use of BPLAB-monitor enabling blood pressure daily registration by oscillographic method. While oscillograms analysis according to T.J.Brinton method the following indices were defined: pulse pressure capacity (dP/dTfall), time interval between extreme points of the first-order derivative (Tpp). In accordance with previously published materials it is thought that arterial compliance inversely proportional to dP/dTfall and Tpp and peripheral resistance is directly proportional to dP/ dTfall and Tpp. The differences between specified indices in groups with arterial hypertension and with no hypertension and their daily dynamics were analyzed as well.
It is established that criterion dP/dTfall 9,66 ± 0,33 mmHg and 7,98 ± 0,42 mmHg  considerably differed in groups with arterial hypertension and with no hypertension accordingly. While daily dynamics analysis it is defined that arterial compliance characterized by dP/dTfall depends on time of day in the both groups. They were 8,34 ± 0,52 mmHg and 6,61 ± 0,43 mmHg (p<0,05) in the group of patients with normal tension, 9,98 ± 0,41 mmHg and 8,35 ± 0,39 mmHg (p<0,05) – in the group of patients with arterial hypertension at daytime and nighttime accordingly. As a research result it is proved that arterial stiffness is a dynamic characteristic. Ambulatory blood pressure monitoring data acquired by oscillographic method can be used for estimation of arterial stiffness dynamics during a day.