Inflammation markers and vascular elasticity parameters of coronary disease patients: stable angina II-III FC intensity patients

Prasolov A.V.
Kursk State Medical University, Kursk, Russia

In the present time special attention is paid to research of proinflammatory cytokines importance in development and progressing of cardiovascular diseases. Processes of vascular elastic properties alterations and their interrelation to immune inflammation in vascular walls are poorly studied.

Purpose: Study relationship between immune inflammation markers (C-reactive protein, IL-1β, IL-6, FNO-α) and vascular walls elasticity parameters among coronary heart disease: stable angina II-III FC intensity patients.

Materials and methods: 80 patients with coronary heart disease: stable angina II-III FC intensity: 65 male (81,2%) and 15 female (18,8%) were examined. The average age is 48,5 ± 6,36 years. Content of FNO-α, IL-1β, IL-6 in blood serum was defined by a method of enzyme-linked immunosorbent assay with the use of test system (“Cytokin”, Russia, “Biomerica” USA). Vascular walls condition parameters were measured with the use of ambulatory blood pressure monitor manufactured by “Petr Telegin” (Nizhny Novgorod) and BPLab-software.

Results: Arterial stiffness increase and vascular elasticity decrease were detected among the examined patients what was defined by a reliable increase of pulse wave velocity up to ± 155,31,3 sm/sec and augmentation index (AIx) to 10,7 ± 0,9 %. Greater damage of vascular walls elastic properties was detected among patients with old infarction in case history. They had larger rates of pulse velocity speed and AIx which exceeded analogue rates of other patients in the same group by 16,6% and 28,6% accordingly. Serumal content of FNO-α among patients with postinfarction cardiosclerosis exceeded by 17,3 % (p<0,05), , IL-1β – by 14,9 % (p<0,05), IL 6 – by 12,5% (p<0,05) in comparison with stable angina II-III patients. C-reactive protein -level among stable angina II-III FC patients was 10,7 ± 1,9 mg/l and was reliably lower than among patients with postinfarction cardiosclerosis (14,1 ± 1,9 mg/l). Direct correlations between IL-1β concentration and pulse wave velocity (r=0,63, p<0,05), IL-6 and pulse wave velocity (r=0,59, p<0,05), FNO-α and pulse wave velocity (r=0,69, p<0,05), C-reactive protein and pulse wave velocity (r=0,71, p<0,05) were detected.